Practice: Calculate the difference in Gibbs free energy between the alternative chair conformations of *trans*-4-iodo-1-cyclohexanol.

For most classes all you will need to know how to do is use equatorial preference to predict the most stable chair conformation.

However, sometimes you will be required to use *energetics* to calculate the __exact percentages of each chair in solution__. This is a multistep process, so here I’m going to walk you through it from scratch.

First we have to introduce the concept of an A-value, which is simply the energy difference between the **equatorial** (most stable) and **axial** (least stable) positions.

Concept #1: Explaining how A-Values are related to cyclohexane flip energy

We can use these values to calculate how much energy it is going to take to flip a chair into its least stable form.

**Note: **The above chair flip in the video is slightly off. Remember that the direction of the groups (up vs. down) should __ not__ change when going from axial to equatorial or vice versa.

**All the math is still correct here**, but I should have drawn the groups down instead of up on the second chair. :)

[Refer to the videos below for examples of this]

Practice: Calculate the difference in Gibbs free energy between the alternative chair conformations of *trans*-4-iodo-1-cyclohexanol.

Practice: Calculate the difference in Gibbs free energy between the alternative chair conformations of *cis*-2-ethyl-1-phenylcyclohexane.