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Ch. 2 - Molecular RepresentationsWorksheetSee all chapters
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Ch. 1 - A Review of General Chemistry
Ch. 2 - Molecular Representations
Ch. 3 - Acids and Bases
Ch. 4 - Alkanes and Cycloalkanes
Ch. 5 - Chirality
Ch. 6 - Thermodynamics and Kinetics
Ch. 7 - Substitution Reactions
Ch. 8 - Elimination Reactions
Ch. 9 - Alkenes and Alkynes
Ch. 10 - Addition Reactions
Ch. 11 - Radical Reactions
Ch. 12 - Alcohols, Ethers, Epoxides and Thiols
Ch. 13 - Alcohols and Carbonyl Compounds
Ch. 14 - Synthetic Techniques
Ch. 15 - Analytical Techniques: IR, NMR, Mass Spect
Ch. 16 - Conjugated Systems
Ch. 17 - Aromaticity
Ch. 18 - Reactions of Aromatics: EAS and Beyond
Ch. 19 - Aldehydes and Ketones: Nucleophilic Addition
Ch. 20 - Carboxylic Acid Derivatives: NAS
Ch. 21 - Enolate Chemistry: Reactions at the Alpha-Carbon
Ch. 22 - Condensation Chemistry
Ch. 23 - Amines
Ch. 24 - Carbohydrates
Ch. 25 - Phenols
Ch. 26 - Amino Acids, Peptides, and Proteins
Ch. 26 - Transition Metals
Intermolecular Forces
How To Determine Solubility
Functional Groups
Additional Guides
London Dispersion Force
Van Der Waals
Johnny Betancourt

By definition, functional groups are specific groups of atoms commonly found across molecules all over the universe, that look and behave similarly when exposed to like conditions.

 P.S. Here’s my 5-minute video on memorizing the 17 most important functional groups.

P.S.S Here is the 49-minute super-comprehensive version if you are not in a time crunch.


Functional groups are some of the first terms you learn to recognize in undergraduate organic chemistry- and they happen to be some of the most important. You’ll need many of these later, for example when you study carbohydrates and protein functional groups in biology.

In this post I’m going to teach you how to memorize them based on this chart:

The 17 most important functional groups chartThe 17 most Important Functional Groups Chart

 Why do we even need functional groups? There are quite literally infinite combinations of molecules found in the universe. We could spend the next 100 years learning the name and reactivity of each molecule separately OR we could try to find some patterns in the chaos. 

Functional groups are those patterns.

Specifically, when compared against each other, they share similarities in polarity, acidity, chemical reactivity, etc.

Thankfully, in undergraduate organic chemistry 1 you’re only going to be responsible to know ~17 of these specific groups. I’m about to give you the functional group run-down of your life, with examples and charts of how to memorize these.

(In Orgo 2 the list gets longer, and I’ll have a separate post for those.) 

HEADS UP: For this topic, I’m going to assume you already know how to represent molecules in skeletal (bond line/line angle) form. Meaning I’ll be dropping all hydrogens and lone pairs. If you still need help with understanding these, feel free to watch my videos on skeletal structure.


     1.     Hydrocarbons: Starting with the Backbone

Alkanes (C-C single covalent bonds) are the skeleton of organic chemistry. For that reason, alkanes are not actually considered functional groups, since they provide the backbone for everything else.

However, by mixing carbons and hydrogens together, you can get a few other combinations of carbon and hydrogen that are uniquely reactive. This is how we get alkenes (C=C double bonds) and alkynes (C≡C triple bonds).  

hydrocarbon-functional-groupsHydrocarbon Functional Groups

Benzene is the name of a 6-membered ring with alternating single and double bonds (like the Clutch Prep Logo), however “benzene” is not really a functional group since it is the name of a single molecule. The group is actually called aromatics or arenes. Thus, benzene is part of an aromatic functional group. We will learn more about the names of benzene derivatives later in the year . 

Remember: The “-R” symbol is used to represent extra hydrocarbon side chains on the molecule that we don’t particularly care about at that moment. 

When you extend benzene off of a carbon chain (-R), you get the side chain functional groups phenyl (directly attached to the main chain) and benzyl (extra –CH2 between the benzene and the main chain). These names are counterintuitive, since it makes logical sense that benzene connected to a main chain is called “benzyl”, but chemists aren’t always logical and that’s just plain wrong. 

I’m just the messenger! Take note. 

Now that we are done with hydrocarbons, let’s talk about carbonyls. 

Intermission: What is a carbonyl and why does it matter?  

Carbonyls are just C=O bonds on your molecule. They are NOT true functional groups since they are an essential component of many different functional groups. Some textbooks call them types of “moieties” (a bonding pattern) but I’m just going to call them carbonyls and expect you to remember that they are not functional groups. 

Carbonyl is not Technically a Functional GroupCarbonyl is not Technically a Functional Group

2. Functional Groups WITHOUT Carbonyls 

When you add single bonded heteroatoms (non-carbon atoms) to alkane chains, you end up getting a bunch of the most essential functional groups for organic chemistry. 

You’ll see soon why the “no carbonyls” part is important in a sec. Here’s the list:

 List of functional groups without carbonylsList of Functional Groups Without Carbonyls

  • When you add any halogen “-X” (Group 7a: -F, -Cl, -Br, -I) you get an alkyl halide (RX)
    • Also known as a haloalkane
    • Specifically called alkyl fluoride, alkyl chloride, alkyl bromide, alkyl iodide
  • When you add any –N (with hydrogens OR carbons attached) you get an amine 
  • When you add an –OH you get an alcohol (ROH)
  • When you add an –OR you get an ether (ROR)
    • Memory Trick: “I’m an ether, ROR! (like you are a scary dinosaur)” 
  • When you add an –SH you get a thiol (RSH)
  •  When you add a -C≡N you get a nitrile (RCN)

CATCH: There are actually several types or “degrees” of these functional groups, but we’ll have to save that for PART 2 (see below). For now, its enough that you just know these groups.

3. Functional Groups WITH Carbonyls

If you take the same functional groups we just memorized and place a carbonyl next to them, you get entirely new compounds.  

List of Carbonyl Functional GroupsList of Carbonyl Functional Groups

When you add a carbonyl to an alkane you actually get two functional groups:

  • When the carbonyl is on the end of carbon chain “terminal” it's called an aldehyde
  • When the carbonyl is in the middle of the carbon chain “internal” it's called a ketone

Now this is where things get interesting!

When you place carbonyls next to the heteroatom-containing functional groups we learned in point 2, many of the new functional groups are given similar names, so its easy to remember which functional groups pair up with which. 

  • Alkyl Halide + Carbonyl = Acid Halide aka Acyl Halide (COX)
    • Acyl chloride, acyl bromide, acyl iodide (acyl fluoride is rarely observed) 
  • Amine + Carbonyl = Amide (CONH3, CONRH2, CONR2H, CONR3
  • Alcohol + Carbonyl = Carboxylic Acid (COOH or CO2H)
  • Ether + Carbonyl = Ester (COOR or CO2R)

The odd man out is carboxylic acid, but as you can see, the names of the other three pairs are almost identical. As long as you remember the first functional group of each pair, you should be able to figure out the other one. 

4. Putting It All Together

The way I’ve organized this chart, similar groups are aligned horizontally and similar pairs are lined up vertically. Now its time for you to put this into practice. 

Can you name the 17 functional groups and fill in the blank spaces in the functional group table without looking above? 

Blank list of functional groupsBlank list of functional groups

Great job (I’m assuming you tried). Now, what’s the difference between a primary alcohol and a tertiary alcohol? We’re going to talk about how to name the degrees of each functional group.


The best way to introduce the concept of degrees is actually to go back to the example of hydrocarbons. 

Example of Hydrocarbon Degrees

Both carbons and hydrogens can be named as methyl (0°), primary (1°), secondary (2°), tertiary (3°), etc. 

The highlighted carbon and hydrogen in this example are both secondary (2), but for very different reasons. 

  • The carbon is secondary because it is directly attached to two other carbons 
  • The hydrogen is also secondary because it is connected to a carbon that is connected (indirectly attached) to two other carbons

See the difference? Hydrogens get their degree from the carbon they are attached to. 

 This rule can be generalized to other atoms and functional groups as well. 

  • Atoms that can form multiple bonds (i.e. C, N) derive degree from direct attachment
  • Atoms/groups that can only form one bond (i.e. –H, –X, –OH) derive degree from indirect attachment

Not all functional groups get degrees by the way. In my functional groups video module, I call the functional groups that get degrees the “A Team”, because they all start with the letter A.

  • Alcohol (R-OH)
  • Alkyl Halide (R-X)
  • Amine (NH3, NRH2, NR2H, NR3)
  • Amide (CONH3, CONRH2, CONR2H, CONR3)

Just by observing these condensed formulas, can you predict which of these groups will derive degree from direct attachment (like carbon) because they can form multiple combinations of bonds? 

If you said the nitrogen-containing functional groups, amine and amide, you are correct! Remember, I said that nitrogen-containing functional groups behave like carbon with respect to degree. 

Pop quiz, can you name the following examples of functional groups along with their degree? I’ve solved the first one for you (answers/explanations at bottom of the page):


Functional Group Examples

Here’s a video of Jonathan identifying functional groups in the gigantic anti-rejection molecule called everolimus (zortress). Can you find them all (including degrees)?

Functional Group Answers: 

2. Aldehyde. It is a carbonyl at the end of a chain with no heteroatoms next to it.

- Even though it starts with “A” sadly aldehyde is not on the A team!

3. Secondary (2°) amine because the nitrogen is directly attached to two carbons 

4. Ester. Looks more confusing in condensed formula, but you need to be able to recognize this. 

5. Primary (1°) alkyl halide (chloride) because the chlorine is indirectly attached to 1 carbon. 

- (Aka the carbon that the chlorine is attached to is only attached to 1 carbon) 

6. Tertiary (3°) amide because the nitrogen is directly attached to 3 carbons 

7. Methyl (0°) alcohol because the oxygen is indirectly attached to zero carbons

- (Aka the carbon that the oxygen is attached is not connected to any other carbons) 

8. Ether. I’m an ether, R-O-R!

9. Ketone. This is a carbonyl in the middle of a chain with no other heteroatoms next to it. Easy to recognize that this is a ketone.

Johnny Betancourt

Johnny got his start tutoring Organic in 2006 when he was a Teaching Assistant. He graduated in Chemistry from FIU and finished up his UF Doctor of Pharmacy last year. He now enjoys helping thousands of students crush mechanisms, while moonlighting as a clinical pharmacist on weekends.