12. Biosignaling
Insulin Signaling on Glucose Metabolism
12. Biosignaling
Insulin Signaling on Glucose Metabolism - Video Tutorials & Practice Problems
On a tight schedule?
Get a 10 bullets summary of the topic1
concept
Insulin Signaling Decreases Blood [Glucose]
Video duration:
13m2
example
Insulin Signaling on Glucose Metabolism Example 1
Video duration:
3m3
concept
Insulin Signaling Activates Glycogen Synthesis
Video duration:
8m4
Problem
ProblemPlace the following insulin signaling transduction events in order of occurrence (event 9 is provided).
a) Full activation of PKB/Akt ______.
b) Activated PI3K converts PIP2 to PIP3 ______.
c) GLUT4 expressed in the cell membrane ___9___.
d) Ligand/insulin binding to the insulin receptor ______.
e) GSK3 is phosphorylated & inactivated ______.
f) Activated PDK1 phosphorylates & activates of PKB/Akt ______.
g) IRS-1 is phosphorylated & activated by the insulin receptor ______.
h) Autophosphorylation of the insulin receptor ______.
i) PI3K is activated upon its SH2 domain binding phosphorylated IRS-1 ______.
j) Glycogen synthase converts glucose to glycogen ______.
k) PIP3 molecules laterally diffuse to bind PKB/Akt & PDK1 ______.
Video duration:
6mWas this helpful?
5
concept
How to Remember Insulin RTK Signaling on Glucose Metabolism?
Video duration:
12m6
example
Insulin Signaling on Glucose Metabolism Example 2
Video duration:
3m7
Problem
ProblemAll of the following are true of the reaction catalyzed by PI3K EXCEPT:
A
Phosphatidylinositol bisphosphate is a substrate of PI3K.
B
Inositol triphosphate is a substrate of PI3K.
C
ATP is a substrate of PI3K.
D
Phosphatidylinositol triphosphate is a product of PI3K.
E
ADP is a product of PI3K.
8
Problem
ProblemWhich of the following results would you predict to occur if a mutation changes a Tyr residue of the Insulin Receptor to Ala?
A
Inability to take up glucose from the bloodstream.
B
Constant uptake of glucose from the bloodstream.
C
Upregulated glycogen synthesis and GLUT4 transport to the membrane.
D
B and C.
9
Problem
ProblemIRS-1 is an essential adaptor protein in the insulin signaling pathway. If IRS-1 was under expressed in muscle cells, what effect would you expect to see on glycogen synthesis?
A
Protein kinase B would remain inactive, resulting in increased glycogen synthesis.
B
Protein kinase B would be overstimulated, resulting in increased glycogen synthesis.
C
Protein kinase B would remain inactive, resulting in decreased glycogen synthesis.
D
Protein kinase B would be overstimulated, resulting in decreased glycogen synthesis.